![]() ![]() ![]() The challenge of the native environment Characterizing viruses and virus-like particles in their native environments is difficult, particularly when it comes to identification of crucial traits that are relevant to API development, production, and targeted applications. “DLS provides the hydrodynamic size of molecules and particles in solution and consequently can measure the size of viruses and VLPs in their native state,” she adds. ![]() In addition, many sample preparation techniques have the potential to impact the structure and properties of virus particles and VLPs.Īs a non-invasive method, dynamic light scattering (DLS) offers many advantages over more traditional approaches such as microscopy, which often require manipulations that can alter the particles, according to Sophia Kenrick, an application scientist with Wyatt Technology. Detection of VLPs can be a challenging task, and any detection method must be able to differentiate virus and VLP particles-which range from tens to hundreds of nm-from proteins. VLPs are designed to mimic the activity of viruses via viral surface proteins, but they lack the infectious genetic material of viruses. Effective analysis of viruses and virus-like particles (VLPs) is crucial for the development of vaccines and drugs. ![]()
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